Epithelia and mesenchyme interact during various physiologic and patho
logic processes. Scatter factor is a mesenchyme-derived cytokine that
stimulates motility, proliferation, and morphogenesis of epithelia. Re
cent studies suggest that scatter factor and its receptor (c-met) medi
ate mesenchyme/epithelia signalling and even interconversion. In this
mini-review, we will discuss how scatter factor and c-met may mediate
interactions between mesenchyme and epithelia during embryogenesis, or
gan repair, and neoplasia.