HOMOZYGOSITY AT THE DOPAMINE D3 RECEPTOR GENE IN SCHIZOPHRENIC-PATIENTS

Citation
N. Durany et al., HOMOZYGOSITY AT THE DOPAMINE D3 RECEPTOR GENE IN SCHIZOPHRENIC-PATIENTS, Neuroscience letters, 220(3), 1996, pp. 151-154
Citations number
19
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences
Journal title
ISSN journal
0304-3940
Volume
220
Issue
3
Year of publication
1996
Pages
151 - 154
Database
ISI
SICI code
0304-3940(1996)220:3<151:HATDDR>2.0.ZU;2-3
Abstract
Dopamine receptors have long been implicated in the etiology of schizo phrenia. It has been reported an association of schizophrenia with hom ozygosity at the dopamine D3 receptor gene locus. We have investigated the distribution of a D3 receptor gene polymorphism (BalI) in 107 sch izophrenic Spanish patients and 100 healthy matched controls. No stati stically significant differences between the patients and control grou p were detected with respect to either allele frequencies or genotype distribution. However, if not corrected for multiple testing, a correl ation was found between homozygosity and early age of onset of schizop hrenia (chi(2) = 3.1, df = 1, P = 0.03) and between Al allele frequenc y and disorganized and undifferentiated schizophrenia (chi(2) = 3.4, d f = 1, P = 0.03; chi(2) = 2.7, df = 1, P = 0.05, respectively). These results suggest the possibility that D3 polymorphisms may be among the physiological factors underlying schizophrenia; though not the determ ining factor. (C) 1996 Elsevier Science Ireland Ltd.