SUPPRESSION OF MONOSODIUM URATE CRYSTAL-INDUCED INFLAMMATION BY BLACK-CURRANT SEED OIL

Authors
Citation
Ga. Tate et Rb. Zurier, SUPPRESSION OF MONOSODIUM URATE CRYSTAL-INDUCED INFLAMMATION BY BLACK-CURRANT SEED OIL, Agents and actions, 43(1-2), 1994, pp. 35-38
Citations number
21
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
ISSN journal
0065-4299
Volume
43
Issue
1-2
Year of publication
1994
Pages
35 - 38
Database
ISI
SICI code
0065-4299(1994)43:1-2<35:SOMUCI>2.0.ZU;2-8
Abstract
The subcutaneous air pouch formed in Sprague-Dawley rats was used to s tudy the effect of diets enriched in black currant seed oil (BCSO) on acute inflammation induced by monosodium urate crystals. The BCSO enri ched diet suppressed significantly both the cellular and fluid phases of inflammation (polymorphonuclear leucocyte and exudate accumulation) . In contrast, administration of normal chow or of a diet enriched in safflower oil (polyunsaturated fatty acid control) did not influence m onosodium urate crystal-induced inflammation in this model. The findin gs indicate that a diet which provides both n-6 (gammalinolenic acid) and n-3 (alpha-linolenic acid) fatty acids as substrates alternative t o arachidonatic acid for oxidative metabolism, modifies monosodium ura te crystal-induced acute inflammation.