REGIONAL BLOOD-FLOW DISTRIBUTION AND LEFT-VENTRICULAR OUTPUT DURING EARLY NEONATAL LIFE - A QUANTITATIVE ULTRASONOGRAPHIC ASSESSMENT

Citation
Y. Agata et al., REGIONAL BLOOD-FLOW DISTRIBUTION AND LEFT-VENTRICULAR OUTPUT DURING EARLY NEONATAL LIFE - A QUANTITATIVE ULTRASONOGRAPHIC ASSESSMENT, Pediatric research, 36(6), 1994, pp. 805-810
Citations number
21
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pediatrics
Journal title
ISSN journal
0031-3998
Volume
36
Issue
6
Year of publication
1994
Pages
805 - 810
Database
ISI
SICI code
0031-3998(1994)36:6<805:RBDALO>2.0.ZU;2-N
Abstract
To examine the serial changes of left ventricular output and regional blood flow distribution during the early neonatal period, we measured blood flow volume in the ascending aorta, middle cerebral artery, celi ac artery, superior mesenteric artery, and renal artery in 23 normal t erm infants at 1, 4-8, 24, and 96 h after birth. The blood flow volume in each vessel was measured by the pulsed Doppler technique. In the m iddle cerebral artery, celiac artery, and superior mesenteric artery, the blood flow volume at 1 and 4-8 h of age was significantly lower th an after 24 h of age. In contrast, renal artery blood flow volume did not change significantly throughout the study period. The reduced orga n blood flow volume soon after birth was related to a low diastolic bl ood flow in the major vessels, and the percent diastolic integral of b lood flow velocity in each vessel showed an inverse linear correlation with the diameter of the ductus arteriosus. The left ventricular outp ut 1 h after birth was 365 +/- 69 mL/kg/min, which was significantly h igher than after 4-8 h of age. Left ventricular output gradually decli ned to 301 +/- 63 mL/kg/min at 4-8 h of age (p < 0.05 versus 96 h), 27 2 +/- 48 mL/kg/min at 24 h, and 258 +/- 54 mL/kg/min at 96 h. There wa s a significant positive correlation between left ventricular output a nd the ductus arteriosus diameter. We concluded that 1) there were sig nificant changes in organ blood flow during the period of ductal closu re, 2) the high left ventricular output and reduced regional blood flo w at 1 and 4-8 h after birth resulted from diastolic left-to-right shu nting through the ductus arteriosus, and 3) left ventricular output an d regional organ blood flow were not directly related to each other. O ur findings on the changes in regional organ blood flow and left ventr icular output may provide a useful basis for interpreting abnormal hem odynamics in the early postnatal period.