CHROMOSOME-ABERRATIONS AFTER TREATMENT WITH RADIOACTIVE IODINE FOR THYROID-CANCER

Citation
L. Baugnetmahieu et al., CHROMOSOME-ABERRATIONS AFTER TREATMENT WITH RADIOACTIVE IODINE FOR THYROID-CANCER, Radiation research, 140(3), 1994, pp. 429-431
Citations number
11
Language
INGLESE
art.tipo
Note
Categorie Soggetti
Radiology,Nuclear Medicine & Medical Imaging
Journal title
ISSN journal
0033-7587
Volume
140
Issue
3
Year of publication
1994
Pages
429 - 431
Database
ISI
SICI code
0033-7587(1994)140:3<429:CATWRI>2.0.ZU;2-B
Abstract
The study aimed to investigate whether the determination of chromosome aberrations in circulating blood lymphocytes could be useful to asses s whole-body exposure from radioactive iodine released accidentally. T en patients treated with two doses of 1850 MBq of I-131 given 24 h apa rt for thyroid cancer were studied for chromosome aberrations (dicentr ics) in blood samples taken before and at various times after exposure . The increase in the yield of aberrations caused by the exposure to i odine was small but statistically significant. Compared to published v alues for whole-body doses after such treatment, this increase appears to be somewhat smaller than expected from dose-effect relationships o btained for an acute exposure of lymphocytes in vitro or in vivo, a fa ct which could be explained by the low dose rate of the I-131 exposure . Thus, in situations where a population was exposed as a result of th e release of radioactive iodine, a determination of chromosome aberrat ions in blood lymphocytes would not appear to be very useful to determ ine exposure from iodine.