A STATISTICAL-THEORY OF CELL-KILLING BY RADIATION OF VARYING LINEAR-ENERGY-TRANSFER

Authors
Citation
Rb. Hawkins, A STATISTICAL-THEORY OF CELL-KILLING BY RADIATION OF VARYING LINEAR-ENERGY-TRANSFER, Radiation research, 140(3), 1994, pp. 366-374
Citations number
11
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Radiology,Nuclear Medicine & Medical Imaging
Journal title
ISSN journal
0033-7587
Volume
140
Issue
3
Year of publication
1994
Pages
366 - 374
Database
ISI
SICI code
0033-7587(1994)140:3<366:ASOCBR>2.0.ZU;2-5
Abstract
A theory is presented that provides an explanation for the observed fe atures of the survival of cultured cells after exposure to densely ion izing high-linear energy transfer (LET) radiation. It starts from a ph enomenological postulate based on the linear-quadratic form of cell su rvival observed for low-LET radiation and uses principles of statistic s and fluctuation theory to demonstrate that the effect of varying LET on cell survival can be attributed to random variation of dose to sma ll volumes contained within the nucleus. A simple relation is presente d for surviving fraction of cells after exposure to radiation of varyi ng LET that depends on the alpha and beta parameters for the same cell s in the limit of low-LET radiation. This relation implies that the va lue of beta is independent of LET. Agreement of the theory with select ed observations of cell survival from the literature is demonstrated. A relation is presented that gives relative biological effectiveness ( RBE) as a function of the alpha and beta parameters for low-LET radiat ion. Measurements from microdosimetry are used to estimate the size of the subnuclear volume to which the fluctuation pertains.