OSTEOGENIC-SARCOMA IN THE ROTHMUND-THOMSON SYNDROME

Citation
A. Leonard et al., OSTEOGENIC-SARCOMA IN THE ROTHMUND-THOMSON SYNDROME, Medical and pediatric oncology, 26(4), 1996, pp. 249-253
Citations number
22
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology,Pediatrics
ISSN journal
0098-1532
Volume
26
Issue
4
Year of publication
1996
Pages
249 - 253
Database
ISI
SICI code
0098-1532(1996)26:4<249:OITRS>2.0.ZU;2-6
Abstract
Two children who had the Rothmund-Thomson syndrome and developed osteo sarcoma are reported. The 10 previously reported cases are reviewed. T he osteosarcomas developed at a younger age than normally expected and 66% occurred in the tibia/fibula. Four of the five patients for whom information was available showed undue sensitivity to cancer chemother apy agents with prolonged myelosuppression and severe mucositis. It is recommended that doxorubicin in particular should be given with extre me caution in such patients. (C) 1996 Wiley-Liss, Inc.