TURNED ON BY CA2- THE PHYSIOLOGY AND PATHOLOGY OF CA2+-BINDING PROTEINS IN THE RETINA( )

Citation
A. Polans et al., TURNED ON BY CA2- THE PHYSIOLOGY AND PATHOLOGY OF CA2+-BINDING PROTEINS IN THE RETINA( ), Trends in neurosciences, 19(12), 1996, pp. 547-554
Citations number
83
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Neurosciences
Journal title
ISSN journal
0166-2236
Volume
19
Issue
12
Year of publication
1996
Pages
547 - 554
Database
ISI
SICI code
0166-2236(1996)19:12<547:TOBCTP>2.0.ZU;2-R
Abstract
Vertebrate photoreceptor cells can signal the absorption of a single p hoton and then modulate their response as the intensity of the light a nd the intensity of the background illumination vary, and it has long been recognized that Ca2+ ions contribute to the underlying processes. Recently, several Ca2+-binding proteins of the EF-hand family were id entified that mediate the actions of Ca2+ during the response to light , Molecular interactions between these Ca2+-binding proteins and their cellular targets are amenable to study owing in part to the unique fe atures of phototransduction. In addition,two of the proteins, recoveri n and guanylate cyclase activating protein (GCAP), appear to be involv ed in separate degenerative diseases of the retina that arise in human s and in animal models of human disease, Information obtained from the se studies should also be relevant to the growing number of homologous proteins found in other neural tissues.