ACONITINE, A MAIN COMPONENT OF ACONITE, INCREASES SPONTANEOUS ACETYLCHOLINE-RELEASE FROM THE FRONTAL CEREBRAL-CORTEX OF FREELY MOVING RATS

Citation
I. Kimura et al., ACONITINE, A MAIN COMPONENT OF ACONITE, INCREASES SPONTANEOUS ACETYLCHOLINE-RELEASE FROM THE FRONTAL CEREBRAL-CORTEX OF FREELY MOVING RATS, Biological & pharmaceutical bulletin, 19(11), 1996, pp. 1440-1442
Citations number
20
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Pharmacy
ISSN journal
0918-6158
Volume
19
Issue
11
Year of publication
1996
Pages
1440 - 1442
Database
ISI
SICI code
0918-6158(1996)19:11<1440:AAMCOA>2.0.ZU;2-N
Abstract
We investigated whether peripherally administered aconitine increases spontaneous acetylcholine (ACh) release from the frontal cerebral cort ex in freely moving rats using in vivo microdialysis, as it relates to aconitine-induced bradycardia estimated by a tail-artery cuff techniq ue in unilateral anterior hypothalamus (AH)-lesion mice. Intraperitone ally administered aconitine significantly increased cortical ACh relea se within 15 min at 10 and 30 mu g/kg. The increasing effect disappear ed 30 min after the administration of aconitine. Aconitine-induced ACh release was not inhibited by intracerebroventricularly preadministere d atropine (1 and 3 mu g/rat). Atropine (1 mu g/mouse) preadministered into the contralateral intact AH in mice did not affect aconitine (30 mu g/kg, i.p.)-induced bradycardia. These results indicate that the c ortical ACh release caused by peripherally administered aconitine does not occur through activation of the central muscarinic receptor, and thus its ACh release may not be concerned with the occurrence of brady cardia.