REGULATION OF EPIDERMAL DIFFERENTIATION BY A DISTAL-LESS HOMEODOMAIN GENE

Citation
Mi. Morasso et al., REGULATION OF EPIDERMAL DIFFERENTIATION BY A DISTAL-LESS HOMEODOMAIN GENE, The Journal of cell biology, 135(6), 1996, pp. 1879-1887
Citations number
43
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cell Biology
Journal title
ISSN journal
0021-9525
Volume
135
Issue
6
Year of publication
1996
Part
2
Pages
1879 - 1887
Database
ISI
SICI code
0021-9525(1996)135:6<1879:ROEDBA>2.0.ZU;2-I
Abstract
The Distal-less-related homeodomain gene Dlx3 is expressed in terminal ly differentiated murine epidermal cells. Ectopic expression of this g ene in the basal cell layer of transgenic skin results in a severely a bnormal epidermal phenotype and leads to perinatal lethality. The basa l cells of affected mice ceased to proliferate, and expressed the prof ilaggrin and loricrin genes which are normally transcribed only in the latest stages of epidermal differentiation. All suprabasal cell types were diminished and the stratum corneum was reduced to a single layer . These data indicate that Dlx3 misexpression results in transformatio n of basal cells into more differentiated keratinocytes, suggesting th at this homeoprotein is an important regulator of epidermal differenti ation.