EFFECTS OF 6-HYDROXYDOPAMINE ON THE OPEN-FIELD ACTIVITY OF STRESSED RATS

Citation
Pe. Beck et al., EFFECTS OF 6-HYDROXYDOPAMINE ON THE OPEN-FIELD ACTIVITY OF STRESSED RATS, Medical science research, 24(11), 1996, pp. 743-744
Citations number
12
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medicine, Research & Experimental
Journal title
ISSN journal
0269-8951
Volume
24
Issue
11
Year of publication
1996
Pages
743 - 744
Database
ISI
SICI code
0269-8951(1996)24:11<743:EO6OTO>2.0.ZU;2-D
Abstract
The purpose of the present work was to analyse the behavioural effects of intracerebroventricular injection of 6-hydroxydopamine (6-OHDA) in rats submitted to immobilisation stress. 6-OHDA is a toxin that destr oys both central and peripheral catecholaminergic terminals. The effec ts of stress and the central administration of 6-OHDA in the open fiel d activity were studied. Activity in the open-field decreased in the s tressed animals and in those injected with 6-OHDA. Stress induces cate cholaminergic activation, while the toxin depletes central catecholami nes. We conclude that a narrow range of catecholamine concentration in the brain seems to be necessary for a stable emotional behaviour.