TISSUE LOCALIZATION OF NERVE GROWTH-FACTOR RECEPTORS - TRK-A AND LOW-AFFINITY NERVE GROWTH-FACTOR RECEPTOR IN NEUROBLASTOMA, PHEOCHROMOCYTOMA, AND RETINOBLASTOMA

Citation
N. Kimura et al., TISSUE LOCALIZATION OF NERVE GROWTH-FACTOR RECEPTORS - TRK-A AND LOW-AFFINITY NERVE GROWTH-FACTOR RECEPTOR IN NEUROBLASTOMA, PHEOCHROMOCYTOMA, AND RETINOBLASTOMA, Endocrine pathology, 7(4), 1996, pp. 281-289
Citations number
23
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pathology,"Endocrynology & Metabolism
Journal title
ISSN journal
1046-3976
Volume
7
Issue
4
Year of publication
1996
Pages
281 - 289
Database
ISI
SICI code
1046-3976(1996)7:4<281:TLONGR>2.0.ZU;2-X
Abstract
The immunohistochemical localization of nerve growth factor receptor ( NGFR)-high-affinity NGFR (trk A) and low-affinity NGFR (LNGFR)-was inv estigated in 23 neuroblastoma group tumors, 18 pheochromocytomas, 2 mi xed neuroendocrine-neural tumors, and 16 retinoblastomas. trk A was ex pressed in the tumor cells of all neuroblastomas, pheochromocytomas, a nd retinoblastomas. Immunoreactive intensity was especially strong in the larger ganglionic tumor cells of ganglioneuroblastoma and ganglion euroma. Messenger RNA (mRNA) of trk A was also strongly expressed in t he ganglionic cells of ganglioneuroblastomas and chromaffin cells of p heochromocytomas by in situ hybridization method. LNGFR was negative i n the tumor cells of neuroblastoma; however, it showed strong immunore activity in ganglionic tumor cells and Schwann cells of ganglioneurobl astoma/ganglioneuroma, and sustentacular cells of pheochromocytoma. Al though normal retina expressed both trk A and LNGFR, tumor cells of re tinoblastoma were positive for only trk A but negative for LNGFR. Such differences in the expression of trk A and LNGFR may reflect neuron-g lial interactions in the survival and maturation of the sympathetic ne rves, retina, and tumors in these tissues.