Xm. Hu et Rm. Kellogg, CHEMOSELECTIVE AND DIASTEREOSELECTIVE CYCLIC KETALIZATION OF OPTICALLY PURE 1-ARYL-2,2-DIMETHYLPROPANE-1,3-DIOLS WITH PHENYLGLYOXAL, Recueil des travaux chimiques des Pays-Bas, 115(9), 1996, pp. 407
Reactions of optically pure 1-aryl-2,2-dimethylpropane-1,3-diols with
phenylglyoxal give diastereomerically pure cyclic ketals under acid ca
talyzed conditions. The structure of one of the products, orophenyl)-5
,5-dimethyl-1,3-dioxane-2-carbaldehyde (7), has been determined by X-r
ay crystallography; reaction takes place at the keto group and the ald
ehyde group is oriented axially.