SOLID-SUPPORT SYNTHESIS OF DIMANNOSYLATED AND TETRAMANNOSYLATED TETRATHYMIDYLIC ACID

Citation
Er. Wijsman et al., SOLID-SUPPORT SYNTHESIS OF DIMANNOSYLATED AND TETRAMANNOSYLATED TETRATHYMIDYLIC ACID, Recueil des travaux chimiques des Pays-Bas, 115(9), 1996, pp. 397
Citations number
18
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry
ISSN journal
0165-0513
Volume
115
Issue
9
Year of publication
1996
Database
ISI
SICI code
0165-0513(1996)115:9<397:SSODAT>2.0.ZU;2-G
Abstract
The easy accessible building units 3,4,6-tetra-O-benzoyl-alpha-D-manno pyranosyl)penyl 2-cyanoethyl N,N-diisopropylphosphoramidite (9) and 2, 2-bis(4,4'-dimethoxytrityloxymethyl)propyl 2-cyanoethyl N,N-diisopropy lphosphoramidite (12) were used for the sequential elongation of immob ilized tetrametric thymidylic acid according to a DNA synthesis protoc ol. Ammonolysis of the individual immobilized adducts led to the isola tion of the target compounds 1 and 2.