MENSTRUAL AND REPRODUCTIVE FACTORS AND BILIARY-TRACT CANCERS

Citation
A. Tavani et al., MENSTRUAL AND REPRODUCTIVE FACTORS AND BILIARY-TRACT CANCERS, European journal of cancer prevention, 5(4), 1996, pp. 241-247
Citations number
21
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology
ISSN journal
0959-8278
Volume
5
Issue
4
Year of publication
1996
Pages
241 - 247
Database
ISI
SICI code
0959-8278(1996)5:4<241:MARFAB>2.0.ZU;2-C
Abstract
The relationship between the risk of biliary tract cancers and menstru al and reproductive factors has been studied in a case-control study c onducted in Milan, northern Italy, between January 1984 and February 1 993 on 31 incident, histologically confirmed cases and 377 controls in hospital for acute, non-neoplastic, non-gynaecological, non-hormone-r elated conditions, Odds ratios (ORs) together with their corresponding 95% confidence intervals (CIs) and the significance of the linear tre nds in risk were estimated by unconditional multiple logistic regressi on, after adjustment for age and cholelithiasis, Menopause was associa ted with a decreased risk of biliary tract cancers (OR 0.2), while lat e menopause and the use of hormone replacement therapy tended to incre ase the risk (ORs 1.8 and 2.2 respectively). Age at menarche and regul ar menstrual cycles were not associated, A trend in risk was found wit h parity, while total abortions and age at first and last birth were n ot related, Thus, the protective effect of early menopause and the app arent association of multiple full-term pregnancies suggest a role of female hormones in the aetiology of biliary tract cancers.