PHOTOCHEMISTRY IN BIOLOGICAL MATRICES - BINDING-SITE PHOTOREACTIVITY OF KETOPROFEN IN SERUM ALBUMINS AND CHIRAL DISCRIMINATION

Citation
C. Festa et al., PHOTOCHEMISTRY IN BIOLOGICAL MATRICES - BINDING-SITE PHOTOREACTIVITY OF KETOPROFEN IN SERUM ALBUMINS AND CHIRAL DISCRIMINATION, Gazzetta chimica italiana, 126(9), 1996, pp. 599-603
Citations number
7
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry
Journal title
ISSN journal
0016-5603
Volume
126
Issue
9
Year of publication
1996
Pages
599 - 603
Database
ISI
SICI code
0016-5603(1996)126:9<599:PIBM-B>2.0.ZU;2-Q
Abstract
Two binding sites for ketoprofen exist in Bovine Serum Albumin resulti ng in remarkably different circular dichroism and photoreactivity on t he antiinflammatory drug, irrespective of its chirality. The slightly different affinity of the ketoprofen antipodes for these sites allows chiral recognition: the resultant photodiscrimination level is, howeve r, too low for processes of photoresolution of practical interest. Ena ntiomer affinity can be tuned by addition of foreign substances. A sim ple model is able to account for the experimental results.