THE CU-A SITE OF CYTOCHROME-C-OXIDASE

Citation
C. Dennison et Gw. Canters, THE CU-A SITE OF CYTOCHROME-C-OXIDASE, Recueil des travaux chimiques des Pays-Bas, 115(7-8), 1996, pp. 345
Citations number
84
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry
ISSN journal
0165-0513
Volume
115
Issue
7-8
Year of publication
1996
Database
ISI
SICI code
0165-0513(1996)115:7-8<345:TCSOC>2.0.ZU;2-5
Abstract
The recent exciting developments concerning the structure and function of the Cu-A site in cytochrome c oxidase (COX) and nitrous oxide redu ctase are reviewed. The XRD structures of a mitochondrial and a bacter ial COX have been reported in 1995, In COX, the Cu-A centre is located in subunit II and is involved in electron transfer from a cytochrome c donor to the oxygen binding centre of the protein. The structural st udies on the enzyme have revealed the coordination geometries of the m any metal centres of COX, including the Cu-A site. A combination of sp ectroscopic and mutagenesis studies on the Cu-A centre led to the corr ect prediction of the structure of this unique copper centre. The cons truction of a Cu-A site in type 1 blue copper proteins is briefly disc ussed.