EFFECTS OF FREUND COMPLETE ADJUVANT ON THE DIURNAL RHYTHMS OF NEUROENDOCRINE PROCESSES AND ORNITHINE DECARBOXYLASE ACTIVITY IN VARIOUS TISSUES OF MALE-RATS

Authors
Citation
M. Neidhart, EFFECTS OF FREUND COMPLETE ADJUVANT ON THE DIURNAL RHYTHMS OF NEUROENDOCRINE PROCESSES AND ORNITHINE DECARBOXYLASE ACTIVITY IN VARIOUS TISSUES OF MALE-RATS, Experientia, 52(9), 1996, pp. 900-908
Citations number
32
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Multidisciplinary Sciences
Journal title
ISSN journal
0014-4754
Volume
52
Issue
9
Year of publication
1996
Pages
900 - 908
Database
ISI
SICI code
0014-4754(1996)52:9<900:EOFCAO>2.0.ZU;2-1
Abstract
The aim of this study was to investigate the effects of Fyeund's compl ete adjuvant (FCA) on the diurnal rhythms of hormonal parameters in se rum and ornithine decarboxylase (ODC) activity in various tissues of m ale rats. On days 1-2 after FCA, increase of ODC activity (used to eva luate the level of activation) was observed in the hypothalamus, pitui tary gland, adrenal medulla, adrenal cortex, liver and lymphoid tissue s, while the ODC activity in the kidney was reduced. This was accompan ied by an increase in serum corticosterone. On days 3-4 after FCA, ODC activity remained elevated in the pituitary gland, liver and lymphoid tissues, while the ODC activity in the testes and pancreas was reduce d; kidney ODC activity returned to baseline. This was associated with increased serum levels of prolactin (Prl) and luteinizing hormone, but decreased growth hormone, testosterone and insulin. The increase in O DC activity in the thymus, as well as the reduced ODC activity in the testes and kidney, can be obtained with paraffin. Furthermore, bromocr yptine microcapsules (CBLA) reduced the FCA-induced increase of ODC ac tivity in the pituitary gland, liver and lymphoid tissues (days 3-4) b ut did not affect the changes in other tissues. The increase in ODC ac tivity in the pituitary gland, liver and lymphoid tissues is specific for FCA. A role for Prl in the induction of ODC in liver and lymphoid tissues is suggested by the fact that CBLA suppresses this enhancement .