THE ACTION OF THE PEPTIDOLEUKOTRIENE LTD(4) ON INTRACELLULAR CALCIUM IN RAT MESANGIAL CELLS

Authors
Citation
M. Ochsner, THE ACTION OF THE PEPTIDOLEUKOTRIENE LTD(4) ON INTRACELLULAR CALCIUM IN RAT MESANGIAL CELLS, Experientia, 52(9), 1996, pp. 856-864
Citations number
54
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Multidisciplinary Sciences
Journal title
ISSN journal
0014-4754
Volume
52
Issue
9
Year of publication
1996
Pages
856 - 864
Database
ISI
SICI code
0014-4754(1996)52:9<856:TAOTPL>2.0.ZU;2-G
Abstract
The dose-dependent effect of CGP 45715A on the LTD(4)-induced Ca2+ res ponse of glomerular mesangial cells has been studied. Our results demo nstrate that the LTD(4)-dependent increase in the cytosolic Ca2+ conce ntration primarily involves an InsP(3)-mediated release of Ca2+ from i ntracellular storage sites and to a minor extent an enhanced influx of Ca2+ through receptor-operated Ca2+ channels located in the plasma me mbrane. The action of CGP 45715A on the Ca2+ response is an inhibitory one and is convincingly explained by a displacement of LTD(4) from it s receptor site(s). The contractile effect of LTD(4) on pulmonary smoo th muscle is proposed to be mainly caused by a receptor-mediated hydro lysis of phosphatidylinoaitol-4 5-bisphosphate.