BLEEDING-TIME AND CONCENTRATIONS OF VON-WILLEBRAND-FACTOR IN PATIENTSWITH ACUTE UPPER GASTROINTESTINAL-BLEEDING

Citation
Ae. Henriksson et al., BLEEDING-TIME AND CONCENTRATIONS OF VON-WILLEBRAND-FACTOR IN PATIENTSWITH ACUTE UPPER GASTROINTESTINAL-BLEEDING, The European journal of surgery, 162(8), 1996, pp. 627-631
Citations number
16
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Surgery
ISSN journal
1102-4151
Volume
162
Issue
8
Year of publication
1996
Pages
627 - 631
Database
ISI
SICI code
1102-4151(1996)162:8<627:BACOVI>2.0.ZU;2-2
Abstract
Objective: To evaluate the prevalence of impaired primary haemostasis in patients with acute upper gastrointestinal bleeding. Design: Prospe ctive open study. Setting: County hospital, Sweden. Subjects: 160 cons ecutive patients admitted with haematemesis or melaena, or both. Inter ventions: Diagnosis verified on admission by endoscopy. Consumption of non-steroidal anti-inflammatory drugs (NSAID), transfusion requiremen ts, presence of chronic liver disease, and age were recorded. Main out come measures: Skin bleeding time was measured on admission with a mod ified Ivy method using the Simplate II bleeding time device; von Wille brand factor and routine haematological tests were analysed. Results: In 31 of the patients (19%) the skin bleeding time was prolonged (over 10 minutes), and these patients also had a significantly lower packed cell volume on admission. In all patients the concentration of von Wi llebrand factor was increased which might explain why there was no sig nificant difference in bleeding time between those who did and those w ho did not take NSAIDs. Conclusion: We recommend measurement of bleedi ng time in patients who present with haematemesis or melaena, or both, to detect those with impaired primary haemostasis.