GENE-EXPRESSION OF ANGIOTENSIN-II RECEPTOR SUBTYPES IN THE CEREBELLARCORTEX OF YOUNG-RATS

Citation
O. Johren et Jm. Saavedra, GENE-EXPRESSION OF ANGIOTENSIN-II RECEPTOR SUBTYPES IN THE CEREBELLARCORTEX OF YOUNG-RATS, NeuroReport, 7(8), 1996, pp. 1349-1352
Citations number
24
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences
Journal title
ISSN journal
0959-4965
Volume
7
Issue
8
Year of publication
1996
Pages
1349 - 1352
Database
ISI
SICI code
0959-4965(1996)7:8<1349:GOARSI>2.0.ZU;2-E
Abstract
BOTH AT(1) and AT(2) receptors were detected in the cerebellar cortex of 2-week-old rats by [I-125]Sar(1)-angiotensin II binding. In contras t, using in situ hybridization histochemistry we found only AT(1A) and AT(1B) but not AT(2) receptor mRNA in the cerebellar cortex of young rats. Expression of AT(1A) and AT(1B) receptor mRNA was restricted to Purkinje cells and no expression of mRNA coding for either receptor su btype was found in the molecular or granular cell layers. Our results suggest that AT(1) receptors may be located on dendrites of Purkinje c ells expressing AT(1A) and AT(1B) receptor mRNA, whereas the AT(2) rec eptor binding in the molecular layer may be located on nerve terminals of fibers projecting to the cerebellar cortex from distant areas.