GARLIC POWDER IN THE TREATMENT OF MODERATE HYPERLIPIDEMIA - A CONTROLLED TRIAL AND METAANALYSIS

Citation
Haw. Neil et al., GARLIC POWDER IN THE TREATMENT OF MODERATE HYPERLIPIDEMIA - A CONTROLLED TRIAL AND METAANALYSIS, Journal of the Royal College of Physicians of London, 30(4), 1996, pp. 329-334
Citations number
15
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medicine, General & Internal
ISSN journal
0035-8819
Volume
30
Issue
4
Year of publication
1996
Pages
329 - 334
Database
ISI
SICI code
0035-8819(1996)30:4<329:GPITTO>2.0.ZU;2-R
Abstract
Objective: to determine the effect of 900 mg/day of dried garlic powde r (standardised to 1.3% allicin) in reducing total cholesterol. Design : double-blind, randomised six-month parallel trial. Subjects: 115 ind ividuals with a repeat total cholesterol concentration of 6.0-8.5 mmol /l and low-density lipoprotein (LDL) cholesterol of 3.5 mmol/l or abov e after six weeks of dietary advice. Intervention: the active treatmen t group received dried garlic tablets (standardised to 1.3% allicin) a t a dosage of 300 mg three times daily. The control group received a m atching placebo. Outcome measures: primary end-point: total cholestero l concentration; secondary end-points: concentrations of LDL and high- density lipoprotein cholesterol, apolipoproteins (ape) Al and B, and t riglycerides. Results: there were no significant differences between t he groups receiving garlic and placebo in the mean concentrations of s erum lipids, lipoproteins or apo Al or B, by analysis either on intent ion-to-treat or treatment received. In a meta-analysis which included the results from this trial, garlic was associated with a mean reducti on in total cholesterol of -0.65 mmol/l (95% confidence intervals: -0. 53 to -0.76). Conclusions: in this trial, garlic was less effective in reducing total cholesterol than suggested by previous meta-analyses. Possible explanations are publication bias, overestimation of treatmen t effects in trials with inadequate concealment of treatment allocatio n, or a type 2 error. We conclude that meta-analyses should be interpr eted critically and with particular caution if the constituent trials are small.