ACYLCARNITINE METABOLISM DURING FASTING AND AFTER REFEEDING

Citation
K. Yamaguti et al., ACYLCARNITINE METABOLISM DURING FASTING AND AFTER REFEEDING, Biochemical and biophysical research communications, 225(3), 1996, pp. 740-746
Citations number
25
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Biology,Biophysics
ISSN journal
0006-291X
Volume
225
Issue
3
Year of publication
1996
Pages
740 - 746
Database
ISI
SICI code
0006-291X(1996)225:3<740:AMDFAA>2.0.ZU;2-B
Abstract
Carnitine metabolism during starvation and just after refeeding was st udied by the measurement of acylcarnitine (ACR) and total carnitine (T CR) concentration in the serum and liver of mice. Starvation caused ma rked increases in the concentration of serum ACR, and of acid-soluble ACR in the liver. The refeeding caused the quick decrement of serum AC R with a concomitant marked increase in the level of acid-soluble TCR in the liver. Through the use of positron emission tomography in a rhe sus monkey, a marked increase in [2-C-11]acetyl-L-carnitine uptake in the liver was observed after the administration of glucose accompanyin g the decrease of serum ACR. From this study, it is clear that the mam malian liver can salvage and conserve the unused ACR when the state of energy metabolism is improved. (C) 1996 Academic Press, Inc.