HISTOPATHOLOGICAL FINDINGS IN PIGS OF VARIOUS AGES SUFFERING FROM SPONTANEOUS INFECTION WITH THE PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS (PRRSV)

Citation
J. Darbes et al., HISTOPATHOLOGICAL FINDINGS IN PIGS OF VARIOUS AGES SUFFERING FROM SPONTANEOUS INFECTION WITH THE PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS (PRRSV), Journal of veterinary medicine. Series A, 43(6), 1996, pp. 353-363
Citations number
29
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Veterinary Sciences
ISSN journal
0931-184X
Volume
43
Issue
6
Year of publication
1996
Pages
353 - 363
Database
ISI
SICI code
0931-184X(1996)43:6<353:HFIPOV>2.0.ZU;2-E
Abstract
A retrospective study was carried out to investigate the morphology of 29 routinely necropsied German Landrace pigs of various ages, namely five fetuses, eight neonates, five suckling piglets and 11 weaners, be ing either serologically PRRSV-positive or born or aborted from PRRSV positive sows. Virus antigen was immunohistochemically demonstrated in 12 out of 27 (44 %) lungs tested. The distinguishing histopathologica l features of PRRSV-induced spontaneous disease are interstitial pneum onia accompanied by secondary inflammatory alterations that become mor e and more pronounced with increasing age, and vascular alterations hi therto not described in animals of these age groups. The latter consis t of vasculitis of the medium-sized arteries and occasionally of the v eins, mainly in the lungs but also in other organs, and of perivascula r lymphoplasmacytic infiltrates of various degrees of frequency and or gan distribution, but present above all in the CNS-including the menin ges and in the lungs. These findings, which suggest vasculotropism on the part of the PRRSV, may facilitate the histopathological diagnosis of PRRSV infections in routinely examined material.