CLASSICAL AND TOPICAL ASPECTS OF PURULENT -MENINGITIS

Citation
A. Ring et al., CLASSICAL AND TOPICAL ASPECTS OF PURULENT -MENINGITIS, Nervenarzt, 67(8), 1996, pp. 630-638
Citations number
30
Language
TEDESCO
art.tipo
Review
Categorie Soggetti
Psychiatry,"Clinical Neurology
Journal title
ISSN journal
0028-2804
Volume
67
Issue
8
Year of publication
1996
Pages
630 - 638
Database
ISI
SICI code
0028-2804(1996)67:8<630:CATAOP>2.0.ZU;2-E
Abstract
Even today acute purulent meningitis is a life-threatening disease req uiring immediate diagnosis and therapy. Despite the availability of ba ctericidal antibiotics, the mortality has not changed within the last 20 years. A therapeutic approach interfering specifically with the pat hogenesis of inflammation is necessary in order to prevent long-term n eurological sequelae and death associated with bacterial meningitis. I n this paper we discuss the present level of understanding of antibiot ics and adjunctive therapy, especially with regard to the molecular pa thophysiological events occurring during a CNS infection.