EFFECTS OF FEMALE SEX-HORMONES ON POLYAMINE-OXIDIZING ENZYME-ACTIVITIES AND POLYAMINE CONCENTRATIONS IN IMMATURE RAT UTERUS AND LIVER

Citation
O. Dimitrov et al., EFFECTS OF FEMALE SEX-HORMONES ON POLYAMINE-OXIDIZING ENZYME-ACTIVITIES AND POLYAMINE CONCENTRATIONS IN IMMATURE RAT UTERUS AND LIVER, Experientia, 52(8), 1996, pp. 795-798
Citations number
21
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Multidisciplinary Sciences
Journal title
ISSN journal
0014-4754
Volume
52
Issue
8
Year of publication
1996
Pages
795 - 798
Database
ISI
SICI code
0014-4754(1996)52:8<795:EOFSOP>2.0.ZU;2-I
Abstract
17 beta-estradiol (E(2)) and progesterone (P) treatment of immature fe male rats (10 mu g/100 g body weight) respectively resulted in 1.38-fo ld (p < 0.02) and 1.42-fold (p < 0.02) increase in the uterine polyami ne oxidase activity, and 2.45-fold (p < 0.001) and 1.43-fold (p < 0.02 ) increase in the uterine diamine oxidase activity, as compared to the controls. E(2) caused a 5-fold (p < 0.05) and a 1.36-fold (p < 0.05) increase in putrescine and spermidine concentration respectively in ra t uterus. Increases of 1.7-fold (p < 0.02) and 1.6-fold (p < 0.05) in putrescine and spermine concentration were determined in the P-treated uterus, as compared to the controls. The spermidine/spermine ratio, w hich is regarded as an index of growth rate, was higher in the E(2)-tr eated uterus and lower in the P-treated uterus than in the control ute rus. No statistically significant hormonal effects were estimated in t he immature liver. The data reported suggest the possibility of an inv olvement of polyamine-oxidizing enzymes in the modulation of polyamine concentrations in rat uterus by the female sex hormones.