GAS-CHROMATOGRAPHIC MASS-SPECTROMETRIC ANALYSIS OF METHYL METHANESULFONATE AND ETHYL METHANESULFONATE IN THE BISMESYLATE SALT OF DPI-201-106, A POSITIVE INOTROPIC AGENT FOR THE TREATMENT OF HEART-FAILURE

Citation
Hg. Ramjit et al., GAS-CHROMATOGRAPHIC MASS-SPECTROMETRIC ANALYSIS OF METHYL METHANESULFONATE AND ETHYL METHANESULFONATE IN THE BISMESYLATE SALT OF DPI-201-106, A POSITIVE INOTROPIC AGENT FOR THE TREATMENT OF HEART-FAILURE, Journal of mass spectrometry., 31(8), 1996, pp. 867-872
Citations number
24
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry Inorganic & Nuclear",Spectroscopy,Biophysics
ISSN journal
1076-5174
Volume
31
Issue
8
Year of publication
1996
Pages
867 - 872
Database
ISI
SICI code
1076-5174(1996)31:8<867:GMAOMM>2.0.ZU;2-A
Abstract
A gas chromatographic/mass spectrometric procedure using single-ion mo nitoring and repetitive scanning was developed to characterize and det ermine methyl methanesulphonate (MMS) and ethyl methanesulphonate (EMS ) in the free base and bismesylate salt of DPI 201-106, a positive ino tropic agent used in the treatment of heart failure, Mass spectral fra gmentations, leading to product ions, are rationalized and mechanisms of potential rearrangement pathways are described. The apparent levels of MMS and EMS, as measured against the internal standard n-propyl me thanesulphonate, were found to be 0.51 and 131 mu g per gram of bismes ylate salt, respectively. The presence of these alkylating agents in t he free base was not observed.