MENSTRUAL AND REPRODUCTIVE FACTORS AND HIP-FRACTURES IN POST MENOPAUSAL WOMEN

Citation
F. Parazzini et al., MENSTRUAL AND REPRODUCTIVE FACTORS AND HIP-FRACTURES IN POST MENOPAUSAL WOMEN, Maturitas, 24(3), 1996, pp. 191-196
Citations number
17
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Geiatric & Gerontology","Obsetric & Gynecology","Medicine, General & Internal
Journal title
ISSN journal
0378-5122
Volume
24
Issue
3
Year of publication
1996
Pages
191 - 196
Database
ISI
SICI code
0378-5122(1996)24:3<191:MARFAH>2.0.ZU;2-F
Abstract
Objectives: We analyzed the relationship between menstrual and reprodu ctive history and risk of hip fractures in post-menopausal women using data from an Italian case-control study. Methods: Cases were 206 post -menopausal women admitted for fractures of the hip/proximal femur to a network of teaching and general hospitals in Milan, Italy. The compa rison group consisted of 590 post-menopausal women admitted to the sam e network of hospitals for acute, non-neoplastic, non-hormone-related conditions, other than traumatic or orthopedic disorders. Odds ratios (OR) of hip fracture were derived from unconditional multiple logistic regression. Results: No relation emerged between risk of hip fracture s and age at menarche, lifelong menstrual cycle pattern and age at men opause. In comparison with women with age at menopause greater than or equal to 53 years, the multivariate OR of hip fractures were 1.2, 1.1 , 1.2 and 0.5 in women with menopause at 50-52, 45-49, 40-44 and befor e 40 years (X(1)(2) trend 0.21). In comparison with nulliparae, the es timated age-adjusted OR was 0.6 (95% confidence interval, CI, 0.4-0.9) for parous women, but the multivariate estimate was not significant ( OR 0.8, 95% CI 0.6-1.3) and the multivariate trend in risk with number of births was not significant either. No relation emerged between hip fractures and age at first and last birth, and history of abortions. Conclusions: This study found no relevant influence of menstrual and r eproductive factors on the risk of hip fractures in post-menopausal wo men. However, this is not in contrast with the observation of a short- term effect of menopause and, more in general, female hormone levels o n osteoporosis and hence on hip fractures.