ACCUMULATION OF ARSENIC SPECIES IN SERUM OF PATIENTS WITH CHRONIC RENAL-DISEASE

ZHANG XR CORNELIS R DEKIMPE J MEES L VANDERBIESEN V DECUBBER A VANHOLDER R

Xr. Zhang et al., ACCUMULATION OF ARSENIC SPECIES IN SERUM OF PATIENTS WITH CHRONIC RENAL-DISEASE, Clinical chemistry, 42(8), 1996, pp. 1231-1237

26

INGLESE

Article

Chemistry Medicinal

Clinical chemistry → ACNP

0009-9147

42

8

1996

1

1231 - 1237

ISI

0009-9147(1996)42:8<1231:AOASIS>2.0.ZU;2-F

Speciation of arsenic was determined in serum of 19 non-hemodialysis ( non-HD) and 18 HD patients, The respective mean values of serum creati nine in these groups were 410 +/- 250 and 914 +/- 173 mu mol/L (refere nce range for healthy subjects: females 50-80; males 57-93 mu mol/L). The mean total arsenic concentrations were 5.12 +/- 5.58 and 6.47 +/- 4.28 mu g/L, respectively (reference value: 0.958 +/- 1.52 mu g/L). Di methylarsinic acid (DMA) and arsenobetaine (AsB) were the major As spe cies in serum of the non-HD and HD patients, with mean values of 0.82 +/- 1.05 and 1.93 +/- 1.51 mu g/L for DMA and 3.55 +/- 4.58 and 3.47 /- 2.89 mu g/L for AsB, respectively. Serum concentrations of inorgani c As and monomethylarsonic acid in both groups were below the detectio n limits for these compounds, Measurement of As concentration before v s after 4 h of HD treatment indicated that 68% of total As in serum wa s removed, as was 16% of the total As in packed cells, The efficiency of DMA and AsB removal during dialysis corresponded to that of total A s.