DETERMINATION OF GALLBLADDER BILE LITHOGENICITY IN PATIENTS WITH PRIMARY BILIARY-CIRRHOSIS

Citation
M. Fracchia et al., DETERMINATION OF GALLBLADDER BILE LITHOGENICITY IN PATIENTS WITH PRIMARY BILIARY-CIRRHOSIS, The Italian Journal of Gastroenterology, 28(5), 1996, pp. 255-260
Citations number
34
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Gastroenterology & Hepatology
ISSN journal
0392-0623
Volume
28
Issue
5
Year of publication
1996
Pages
255 - 260
Database
ISI
SICI code
0392-0623(1996)28:5<255:DOGBLI>2.0.ZU;2-H
Abstract
Patients,vith primary biliary cirrhosis have a higher prevalence of ga llstone disease, Aim of this study was to determine whether gallbladde r bile of these patients is lithogenic. We studied 11 patients with ea rly stage primary biliary cirrhosis, and compared them with 16 control subjects, We combined a cholescintigraphic method with nasoduodenal b ile sampling to measure the mass of lipids within the gallbladder. Cho lesterol saturation index, as measured by standard techniques, was sim ilar in patients with primary biliary cirrhosis and controls (medians: 0.85 vs 0.90), Primary biliary cirrhosis patients showed a significan t reduction in the masses of cholesterol, phospholipids and bile acids , as well as in percent biliary deoxycholic acid, as measured by high pressure liquid chromatography (medians 8.6% vs 17.4% in controls; p<0 .05), Percent deoxycholic acid directly correlated with cholesterol ma ss in all subjects (r=0.48; p<0.05). Biliary lipid coupling were simil ar in the two groups, We conclude that, in patients with early stage p rimary biliary cirrhosis, gallbladder bile is not lithogenic and bilia ry lipid coupling is normal, due to a parallel reduction in the masses of cholesterol, phospholipids and bile acids, The significant reducti on in percent deoxycholic acid, characteristic of cholestasis, may hel p explain this biliary lipid mass pattern, that differs from that of c holesterol gallstone patients.