A PHASE-I STUDY OF WEEKLY CISPLATIN AND WHOLE ABDOMINAL RADIATION FORTHE TREATMENT OF STAGE-III AND STAGE-IV ENDOMETRIAL CARCINOMA - A GYNECOLOGIC-ONCOLOGY-GROUP PILOT-STUDY

Citation
Sa. Reisinger et al., A PHASE-I STUDY OF WEEKLY CISPLATIN AND WHOLE ABDOMINAL RADIATION FORTHE TREATMENT OF STAGE-III AND STAGE-IV ENDOMETRIAL CARCINOMA - A GYNECOLOGIC-ONCOLOGY-GROUP PILOT-STUDY, Gynecologic oncology, 63(3), 1996, pp. 299-303
Citations number
13
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology,"Obsetric & Gynecology
Journal title
ISSN journal
0090-8258
Volume
63
Issue
3
Year of publication
1996
Pages
299 - 303
Database
ISI
SICI code
0090-8258(1996)63:3<299:APSOWC>2.0.ZU;2-7
Abstract
A Gynecologic Oncology Group Phase I study was designed to evaluate th e toxicity of whole abdominal radiation therapy with concurrent weekly cisplatin in patients with surgical International Federation of Gynae cology and Obstetrics (FIGO) Stage III and IV endometrial carcinoma, C isplatin 15 mg/m(2) was given once weekly during radiation therapy to the whole abdomen with a pelvic boost and optional para-aortic radiati on, All eight patients received the prescribed dose of radiation thera py, Cisplatin chemotherapy was halted in one patient due to increased serum creatinine after three cycles. Acute adverse effects were within acceptable limits, with one patient admitted to the hospital after co mpletion of treatment for diarrhea, Hematopoietic toxicity was clinica lly unimportant. Serious late toxicities included one radiation enteri tis requiring a bowel resection and chylous ascites in one patient, Th ere was no late renal damage reported, This regimen appears to be tole rated acutely and the late toxicities were similar to those seen with whole abdominal radiation therapy alone. (C) 1996 Academic Press, Inc.