EXTRACELLULAR UBIQUITIN REGULATES THE GROWTH OF HUMAN HEMATOPOIETIC-CELLS

Citation
H. Daino et al., EXTRACELLULAR UBIQUITIN REGULATES THE GROWTH OF HUMAN HEMATOPOIETIC-CELLS, Biochemical and biophysical research communications, 223(2), 1996, pp. 226-228
Citations number
13
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Biology,Biophysics
ISSN journal
0006-291X
Volume
223
Issue
2
Year of publication
1996
Pages
226 - 228
Database
ISI
SICI code
0006-291X(1996)223:2<226:EURTGO>2.0.ZU;2-Z
Abstract
We investigated the effects of extracellular ubiquitin on the colony f ormation of human hematopoietic progenitor cells (CFU-GM, CFU-E and BF U-E) and a granulocyte-colony stimulating factor (G-CSF)-dependent hum an myeloblastic leukemic cell line, OCI/AML/1a. Ubiquitin exhibited in hibitory effects on CFU-GM, CFU-E, BFU-E and OCI/AML/1a colony formati on. Extracellular ubiquitin also inhibited the growth of KT3 (T lympho blast), K562 (erythroleukemia) and Daudi (Burkitt's lymphoma) cells, s timulated the growth of HL60 (promyelocytic leukemia) and Jurkat (T-AL L) cells and showed no effect on the growth of U937 cells (monocytic l eukemia). These results indicate that another, previously unrecognized function of extracellular ubiquitin is to regulate hematopoiesis. (C) 1996 Academic Press, Inc.