C. Maesawa et al., LOSS OF HETEROZYGOSITY AT THE DCC GENE LOCUS IS NOT CRUCIAL FOR THE ACQUISITION OF METASTATIC POTENTIAL IN ESOPHAGEAL SQUAMOUS-CELL CARCINOMA, European journal of cancer, 32A(5), 1996, pp. 896-898
Tumour specimens from 111 patients with oesophageal squamous cell carc
inoma were screened for loss of heterozygosity (LOH) at the deleted co
lorectal carcinoma (DCC) gene locus. DCC-LOH ocurred in 10 of 61 infor
mative cases (16%). No statistically significant correlation was obser
ved between DCC-LOH and lymph node metastasis, histopathological grade
or tumour stage. The survival of patients exhibiting DCC-LOH was not
statistically different from that of patients without LOH. These resul
ts suggest that LOH at the DCC locus is not related to the acquisition
of metastatic potential or the state of tumour cell differentiation i
n oesophageal squamous cell carcinoma. Copyright (C) 1996 Elsevier Sci
ence Ltd