LOSS OF HETEROZYGOSITY AT THE DCC GENE LOCUS IS NOT CRUCIAL FOR THE ACQUISITION OF METASTATIC POTENTIAL IN ESOPHAGEAL SQUAMOUS-CELL CARCINOMA

Citation
C. Maesawa et al., LOSS OF HETEROZYGOSITY AT THE DCC GENE LOCUS IS NOT CRUCIAL FOR THE ACQUISITION OF METASTATIC POTENTIAL IN ESOPHAGEAL SQUAMOUS-CELL CARCINOMA, European journal of cancer, 32A(5), 1996, pp. 896-898
Citations number
10
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology
Journal title
ISSN journal
0959-8049
Volume
32A
Issue
5
Year of publication
1996
Pages
896 - 898
Database
ISI
SICI code
0959-8049(1996)32A:5<896:LOHATD>2.0.ZU;2-A
Abstract
Tumour specimens from 111 patients with oesophageal squamous cell carc inoma were screened for loss of heterozygosity (LOH) at the deleted co lorectal carcinoma (DCC) gene locus. DCC-LOH ocurred in 10 of 61 infor mative cases (16%). No statistically significant correlation was obser ved between DCC-LOH and lymph node metastasis, histopathological grade or tumour stage. The survival of patients exhibiting DCC-LOH was not statistically different from that of patients without LOH. These resul ts suggest that LOH at the DCC locus is not related to the acquisition of metastatic potential or the state of tumour cell differentiation i n oesophageal squamous cell carcinoma. Copyright (C) 1996 Elsevier Sci ence Ltd