THE STREPTOZOCIN-DIABETIC STATE DEPRESSES SALIVA SECRETION STIMULATEDBY PILOCARPINE AND NORADRENALINE IN MICE

Citation
I. Kimura et al., THE STREPTOZOCIN-DIABETIC STATE DEPRESSES SALIVA SECRETION STIMULATEDBY PILOCARPINE AND NORADRENALINE IN MICE, Biological & pharmaceutical bulletin, 19(3), 1996, pp. 384-387
Citations number
11
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Pharmacy
ISSN journal
0918-6158
Volume
19
Issue
3
Year of publication
1996
Pages
384 - 387
Database
ISI
SICI code
0918-6158(1996)19:3<384:TSSDSS>2.0.ZU;2-M
Abstract
We investigated the influence of the streptozocin (STZ)-diabetic state on the dose-response curves for salivary flow and protein content in saliva stimulated by pilocarpine and noradrenaline in mice, The diabet ic state increased the relative weights of parotid and sublingual sali vary glands but not the weight of submandibular glands, despite body w eight loss. In the dose-response curves, (1) the maximal responses to stimulation with pilocarpine and noradrenaline on salivary flow, and w ith noradrenaline on protein content in saliva, were depressed by the diabetic state, and (2) the value of the 50% effective dose for saliva ry flow with pilocarpine, but not with noradrenaline, was decreasingly altered by diabetic mice. These results suggest that xerostomia, one of the complications of noninsulin-dependent diabetes mellitus, is cau sed in part by muscarinic and adrenergic receptor dysfunction in the s alivary glands.