AUTOIMMUNE HEMOLYTIC-ANEMIA IN ALLERGIC GRANULOMATOUS ANGITIS (CHURG-STRAUSS-SYNDROME)

Citation
K. Kojima et al., AUTOIMMUNE HEMOLYTIC-ANEMIA IN ALLERGIC GRANULOMATOUS ANGITIS (CHURG-STRAUSS-SYNDROME), International journal of hematology, 63(2), 1996, pp. 149-154
Citations number
17
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Hematology
ISSN journal
0925-5710
Volume
63
Issue
2
Year of publication
1996
Pages
149 - 154
Database
ISI
SICI code
0925-5710(1996)63:2<149:AHIAGA>2.0.ZU;2-0
Abstract
We describe a patient with allergic granulomatous angitis who develope d autoimmune hemolytic anemia (AIHA). A 44-year-old male had been suff ering from bronchial asthma. On admission, laboratory tests revealed t he presence of severe eosinophilia (21 500/mu l), elevation of total i mmunoglobulin E (IgE), high lactic dehydrogenase (LDH) and low haptogl obin levels, in addition to moderate reticulocytosis. During admission , the patient showed almost simultaneous occurrence of vasculitis in t he extremities, severe hemolysis and exacerbation of asthma in relatio n to the progression of eosinophilia. Both IgM and IgG autoantibodies were considered to be responsible for hemolysis. Interestingly, serum levels of interleukin-4 (IL-4) and IL-5 were increased in association with eosinophilia and increased IgE production. These findings suggest that the AIHA in this patient is mediated or enhanced at least partly by high IL-4 and IL-5 production. Although AIHA in this syndrome is v ery rare, it should be considered as a clinical manifestation.