FACTORS AFFECTING PROGNOSIS OF IDIOPATHIC INTERSTITIAL PNEUMONIA

Citation
K. Matsuo et al., FACTORS AFFECTING PROGNOSIS OF IDIOPATHIC INTERSTITIAL PNEUMONIA, Acta medica Okayama, 50(1), 1996, pp. 37-46
Citations number
30
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medicine, Research & Experimental
Journal title
ISSN journal
0386-300X
Volume
50
Issue
1
Year of publication
1996
Pages
37 - 46
Database
ISI
SICI code
0386-300X(1996)50:1<37:FAPOII>2.0.ZU;2-F
Abstract
Idiopathic interstitial pneumonia (IIP) is a progressive and often fat al pulmonary disorder, and evaluating the prognosis of patients with I IP has never been sufficient. Accordingly, factors including clinical features, laboratory data, cellular components in bronchoalveolar lava ge (BAL) fluid and response to corticosteroid therapy were analyzed in 35 patients with IIP whose median age of respiratory onset was 60 yea rs (range; 37-77 years). Nineteen patients (54.3%) were in the active stage of IIP and 16 of them were treated with corticosteroids. Signifi cant prognostic factors were the neutrophil percentage in BAL fluid, i nterstitial shadows on chest radiograph, pulmonary function, blood oxy gen level, grade of dyspnea, and disease activity at the initial exami nation. Patients in the active stage showed higher proportions of neut rophils and eosinophils in BAL fluid than those in the nonactive stage . Despite corticosteroid therapy, the survival of patients in the acti ve stage was significantly shorter than those in the non-active stage. Fifty percent of the patients treated with corticosteroids were regar ded as responders at 1 month after the initiation of therapy; however, there was no significant difference between responders and non-respon ders in terms of survival time. In conclusion, disease activity and ne utrophils in BAL fluid may be important predictors of the prognosis of IIP.