MONTE-CARLO CALCULATIONS OF ION PASSAGES THROUGH BRAIN ENDOTHELIAL NUCLEI DURING BORON NEUTRON-CAPTURE THERAPY

Citation
De. Charlton et Bj. Allen, MONTE-CARLO CALCULATIONS OF ION PASSAGES THROUGH BRAIN ENDOTHELIAL NUCLEI DURING BORON NEUTRON-CAPTURE THERAPY, International journal of radiation biology, 64(6), 1993, pp. 739-747
Citations number
17
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Radiology,Nuclear Medicine & Medical Imaging","Nuclear Sciences & Tecnology
ISSN journal
0955-3002
Volume
64
Issue
6
Year of publication
1993
Pages
739 - 747
Database
ISI
SICI code
0955-3002(1993)64:6<739:MCOIPT>2.0.ZU;2-U
Abstract
The Monte Carlo technique is used to examine the passage of ions from the (n, p) reaction in nitrogen and the (n, alpha) reaction in B-10 th rough the nuclei of endothelial capillary wall cells of normal white m atter. Contributions to the dose from different regions are evaluated, as is the distribution of doses to the nuclei for mean doses from 1 t o 100 Gy. Calculation of mean dose to the nuclei is generalized for an y neutron fluence and element concentration. The dose-averaged LETs fo r both reactions are found giving (for the particular conditions of th e calculation); 60 keV/mum for the (n, p) reaction and 216 keV/mum for the (n, a) reaction in boron limited to the lumen, and 224 keV/mum fo r a uniform distribution of boron. From a consideration of 'minimal su rvival' and hit and dose distributions, evidence is presented which su ggests that the RBE for the (n, alpha) reaction depends upon the distr ibution of the boron in the tissue, with the uniform distribution bein g less effective at cell killing than the boron restricted to the lume n for the same mean dose to the cell nuclei.