RADIOSENSITIZATION BY NICKEL LAPACHOL

Citation
Ka. Skov et al., RADIOSENSITIZATION BY NICKEL LAPACHOL, International journal of radiation biology, 64(6), 1993, pp. 707-713
Citations number
49
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Radiology,Nuclear Medicine & Medical Imaging","Nuclear Sciences & Tecnology
ISSN journal
0955-3002
Volume
64
Issue
6
Year of publication
1993
Pages
707 - 713
Database
ISI
SICI code
0955-3002(1993)64:6<707:RBNL>2.0.ZU;2-W
Abstract
The properties of interest in the radiosensitization of a metal comple x, nickel lapachol, are compared with those of the 2-nitroimidazole, m isonidazole. These very different comPounds were found to be surprisin gly similar in terms of their reduction potential (- 370 mV), enhancem ent ratios for killing of hypoxic Chinese hamster ovary cells by X-irr adiation, and enhancement of DNA breaks in hypoxia. For nitroimidazole s, the sensitization depends on 'electron affinity', reduction of the nitro group; for nickel lapachol it is the metal which is necessary fo r reduction, yet the sensitization efficiencies are remarkably close. However, the metal complex has additional activities (some sensitizati on in aerobic cells; increased sensitization with preincubation) which are as yet unexplained but are assumed to be related to the nature of the naphthoquinone ligand, rather than to the reduction of the metal.