THE ROLE OF MIP-1-ALPHA IN INFLAMMATION AND HEMATOPOIESIS

Authors
Citation
Dn. Cook, THE ROLE OF MIP-1-ALPHA IN INFLAMMATION AND HEMATOPOIESIS, Journal of leukocyte biology, 59(1), 1996, pp. 61-66
Citations number
40
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Immunology,Hematology
ISSN journal
0741-5400
Volume
59
Issue
1
Year of publication
1996
Pages
61 - 66
Database
ISI
SICI code
0741-5400(1996)59:1<61:TROMII>2.0.ZU;2-P
Abstract
Macrophage inflammatory protein 1 alpha (MIP-1 alpha) is a member of t he C-C subfamily of chemokines, a large superfamily of low-molecular-w eight, inducible proteins that exhibit a variety of proinflammatory ac tivities in vitro including leukocyte chemotaxis, MIP-1 alpha is a par ticularly interesting chemokine, because in addition to its proinflamm atory activities, it inhibits the proliferation of hematopoietic stem cells in vitro and in vivo, Here, the biologic: properties of MIP-1 al pha are reviewed in light of recent data on mice homozygous for a disr uption of the MIP-1 alpha gene. The MIP-1 alpha null mice have no over t abnormalities of peripheral blood or bone marrow cells, indicating t hat MIP-1 alpha is not necessary for normal hematopoiesis. However, th e MIP-1 alpha null mice have a reduced inflammatory response to influe nza virus and are resistant to coxsackievirus-induced myocarditis, The se data demonstrate that MIP-1 alpha is required for a normal inflamma tory response to these viruses. Agents that inhibit the action of MIP- 1 alpha may therefore prove useful for controlling inflammation in the se and other settings.