HOW TO GET THE BEST OUT OF ANTABUSE

Authors
Citation
H. Kristenson, HOW TO GET THE BEST OUT OF ANTABUSE, Alcohol and alcoholism, 30(6), 1995, pp. 775-783
Citations number
47
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Substance Abuse
Journal title
ISSN journal
0735-0414
Volume
30
Issue
6
Year of publication
1995
Pages
775 - 783
Database
ISI
SICI code
0735-0414(1995)30:6<775:HTGTBO>2.0.ZU;2-W
Abstract
In the field of alcoholism treatment, disulfiram or calcium carbimide is one part of the treatment package and these deterrent drugs have to be combined with counselling and support to be effective. Besides ade quate dosage and formulation of substance, the Antabuse tablet has to be taken under supervision by a therapist to strengthen compliance and motivate the patient to continue longterm treatment. Disulfiram metab olism is very complex and although new metabolites have been identifie d, clinically useful and practical determination of active substances for routine use has not been developed. In clinical situations, the di sulfiram-ethanol reaction (DER) is still of major importance to demons trate the effectiveness of the drug. This reaction was originally used to induce aversive conditioning. In the course of time, emphasis has focused more on sobriety and the DER has been used as a positive reinf orcement during treatment. Antabuse therapy is remarkably free of seri ous side-effects. The latency time from start of treatment to the mani festation of adverse drug reactions differs according to organ. Hepato toxicity has special interest in women with nickel dermatitis.