THE PHARMACOLOGICAL TREATMENT OF ALCOHOLISM - FROM BASIC SCIENCE TO CLINICAL MEDICINE

Authors
Citation
Pmp. Verbanck, THE PHARMACOLOGICAL TREATMENT OF ALCOHOLISM - FROM BASIC SCIENCE TO CLINICAL MEDICINE, Alcohol and alcoholism, 30(6), 1995, pp. 757-764
Citations number
81
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Substance Abuse
Journal title
ISSN journal
0735-0414
Volume
30
Issue
6
Year of publication
1995
Pages
757 - 764
Database
ISI
SICI code
0735-0414(1995)30:6<757:TPTOA->2.0.ZU;2-3
Abstract
Recent advances in the understanding of the neurobiological basis of a lcohol dependence have led to the development of pharmacological agent s for the treatment of drinking problems. However, alcoholism is a com plex disease with psychological and social dimensions in addition to m edical problems. This implies that, in this domain, pharmacotherapy mu st be integrated in a general strategy of treatment and directed to sp ecific aspects of management of the disease, such as treatment or prev ention of the withdrawal syndrome or prevention of relapse after detox ification. Whereas the treatment of the withdrawal syndrome with pharm acological agents such as the benzodiazepines is now an established pr actice, the use of drugs for other dimensions of the disease is more c ontroversial. However, the pharmacological approach aimed towards prev ention of relapse appears promising, by means of classical medications such as disulfiram or new drugs (e.g. opiate antagonists and acampros ate). The clinical evaluation of such medications requires guidelines that will permit extrapolation of the results of the trials to situati ons that are commonly faced by practitioners.