PARENTAL HISTORY OF ALCOHOLISM - A RISK FACTOR FOR ALCOHOL-RELATED PERIPHERAL NEUROPATHIES

Citation
F. Pessione et al., PARENTAL HISTORY OF ALCOHOLISM - A RISK FACTOR FOR ALCOHOL-RELATED PERIPHERAL NEUROPATHIES, Alcohol and alcoholism, 30(6), 1995, pp. 749-754
Citations number
24
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Substance Abuse
Journal title
ISSN journal
0735-0414
Volume
30
Issue
6
Year of publication
1995
Pages
749 - 754
Database
ISI
SICI code
0735-0414(1995)30:6<749:PHOA-A>2.0.ZU;2-K
Abstract
The aim of this study was to identify the risk factors of alcohol-rela ted peripheral neuropathies. A case-control study was performed to com pare two groups of alcoholic patients, one with peripheral neuropathy and the other without: but with alcohol-related cirrhosis, pancreatiti s or cardiomyopathy. Ninety patients were recruited in four in-patient units of a French hospital: 32 patients had a peripheral neuropathy a nd 58 patients did not. Univariate analysis showed no differences betw een the two groups for sex, age, body mass index and duration of the a lcoholic disease. Peripheral neuropathies were associated with a highe r frequency of parental history of alcoholism, severity of alcohol dep endence, heavier alcohol consumption and more alcohol-related somatic diseases. Multivariate analysis showed a strong relationship between a parental history of alcoholism and the presence of a neuropathy, when the severity of the alcoholic disease was taken into account (adjuste d OR = 6.8, IC95% [2.2-21.6], P<0.001). The hypothesis that neuropathy may be a marker of an inherited susceptibility to alcoholism is discu ssed.