24-HOUR INTRAGASTRIC ACIDITY - 300 MG RANITIDINE BD, 20 MG OMEPRAZOLEOM, 40 MG OMEPRAZOLE OM VS PLACEBO

Citation
Gmp. Houben et al., 24-HOUR INTRAGASTRIC ACIDITY - 300 MG RANITIDINE BD, 20 MG OMEPRAZOLEOM, 40 MG OMEPRAZOLE OM VS PLACEBO, Alimentary pharmacology & therapeutics, 9(6), 1995, pp. 649-654
Citations number
30
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Pharmacy","Gastroenterology & Hepatology
ISSN journal
0269-2813
Volume
9
Issue
6
Year of publication
1995
Pages
649 - 654
Database
ISI
SICI code
0269-2813(1995)9:6<649:2IA-3M>2.0.ZU;2-6
Abstract
Background: There is considerable controversy about the degree of acid suppression that is optimal for the treatment of peptic disorders. Ai m: To compare the effects of three different regimens that are reporte d to strongly inhibit acid secretion. Methods: Intragastric 24-hour pH monitoring was performed in 11 healthy subjects in a randomized, mult iple, cross-over, double-blind study, Each subject received four dose regimens, each for 2 weeks, in a random order. The regimens were: 300 mg ranitidine b.d., 20 mg omeprazole o.m., 40 mg omeprazole o.m., and placebo. Results: The decrease in gastric acidity during the daytime a nd during the total 24-hour period by all three treatments was signifi cantly greater than after placebo; a significant difference in acid in hibition was found between ranitidine and 40 mg omeprazole, but not be tween ranitidine and 20 mg omeprazole, nor between the two doses of om eprazole, During the night-time the decrease in gastric acidity by all three treatments was significantly greater than after placebo; no dif ference was seen between the two doses of omeprazole and ranitidine, F or the time of pH greater than 3 we found no statistical difference be tween the various acid decreasing regimens, The pH remained significan tly longer above 4 after ranitidine and the two doses of omeprazole co mpared with placebo, and also longer above 4 after 40 mg omeprazole co mpared with ranitidine, but not after 20 mg omeprazole compared with r anitidine, nor after the two different doses of omeprazole. Conclusion s: Dosing with 300 mg ranitidine b.d., 20 mg omeprazole or 40 mg omepr azole is superior in gastric acid inhibition compared with placebo, wh en measured using 24-hour pH monitoring.