HIV-1 GP120-INDUCED NEUROTOXICITY TO MIDBRAIN DOPAMINE CULTURES

Citation
Ba. Bennett et al., HIV-1 GP120-INDUCED NEUROTOXICITY TO MIDBRAIN DOPAMINE CULTURES, Brain research, 705(1-2), 1995, pp. 168-176
Citations number
74
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
0006-8993
Volume
705
Issue
1-2
Year of publication
1995
Pages
168 - 176
Database
ISI
SICI code
0006-8993(1995)705:1-2<168:HGNTMD>2.0.ZU;2-M
Abstract
HIV-1-associated cognitive/motor dysfunction is a frequent neurologica l complication of acquired immunodeficiency syndrome (AIDS) and has be en termed AIDS dementia complex (ADC). The HIV-1 envelope glycoprotein gp120 has been implicated in producing brain injury associated with A DC. The purpose of the present study was to determine if gp120-induced neurotoxicity is associated with damage to dopaminergic systems. Expo sure of rat midbrain dopamine cultures to gp120 for 3 days reduced the ability of dopaminergic cells to transport this amine and also result ed in a reduction in dopamine neuron process length while it did not a lter either dopamine cell number or the total number of neuronal cells . These detrimental effects of gp120 were prevented by an NMDA recepto r antagonist (MK-801) or by preincubation with anti-gp120 antibody. Th ese results suggest that dopaminergic neuronal damage may contribute t o the manifestations of AIDS dementia complex.