THE EFFECTS OF SELECTIVE A(1) AND A(2A) ADENOSINE RECEPTOR ANTAGONISTS ON CEREBRAL ISCHEMIC-INJURY IN THE GERBIL

Authors
Citation
Jw. Phillis, THE EFFECTS OF SELECTIVE A(1) AND A(2A) ADENOSINE RECEPTOR ANTAGONISTS ON CEREBRAL ISCHEMIC-INJURY IN THE GERBIL, Brain research, 705(1-2), 1995, pp. 79-84
Citations number
52
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences
Journal title
ISSN journal
0006-8993
Volume
705
Issue
1-2
Year of publication
1995
Pages
79 - 84
Database
ISI
SICI code
0006-8993(1995)705:1-2<79:TEOSAA>2.0.ZU;2-5
Abstract
Cerebral ischemia of 5 min duration was induced in unanesthetized Mong olian gerbils by bilateral occlusion of the carotid arteries. The exte nt of ischemic injury was assessed behaviorally by measuring the incre ases in locomotor activity following ischemia and by a histopathologic al assessment of the extent of CA1 hippocampal pyramidal cell injury a nd loss 5 days after ischemia. The A(2a) adenosine receptor selective antagonists 8-(3-chlorostyryl) caffeine (CSC; 0.1 mg/kg i.p.) and 4-am ino-1-phenyl[1,2,4]-triazolo[4,3-a] quinoxaline (CP 66,713; 0.1 mg/kg i.p.) reduced the extent of ischemia-induced injury. An A, selective r eceptor antagonist, 8-cyclopentyl-1,3-dipropylxanthine (DPCPX; 1.0 mg/ kg i.p.), enhanced ischemia-evoked injury. These results suggest that adenosine A(2a) receptor antagonists may be useful for the prevention of cerebral injuries resulting from stroke or cardiac arrest.