In order to define elements which may be involved in regulating human
rhodopsin expression, we have isolated and sequenced a clone containin
g 5.34 kb of the 5'-upstream region of the human rhodopsin-encoding ge
ne. The 5.34-kb human segment contains multiple potential transcriptio
n factor-binding sites and a subfamily of Alu repeats. The same subfam
ily of Alu repeats is found 5.8 kb upstream from the human red/green v
isual pigment-encoding gene.