ADJUNCTIVE MAGNESIUM INFUSION THERAPY IN ACUTE MYOCARDIAL-INFARCTION

Citation
B. Bhargava et al., ADJUNCTIVE MAGNESIUM INFUSION THERAPY IN ACUTE MYOCARDIAL-INFARCTION, International journal of cardiology, 52(2), 1995, pp. 95-99
Citations number
19
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Cardiac & Cardiovascular System
ISSN journal
0167-5273
Volume
52
Issue
2
Year of publication
1995
Pages
95 - 99
Database
ISI
SICI code
0167-5273(1995)52:2<95:AMITIA>2.0.ZU;2-L
Abstract
Intravenous magnesium therapy in acute myocardial infarction (MI) has been shown to be beneficial in many studies. However, these effects ar e not consistent from one trial to another, and their clinical signifi cance is often questionable. A total of 78 consecutive patients were i ncluded in a prospective placebo controlled, randomized study of the e ffects of intravenous magnesium sulfate infusion in acute MI. Of these , 52 (66%) received intravenous streptokinase and the rest belonged to a non-thrombolysed group. These patients were randomized to receive m agnesium sulfate infusion (8 mmol over 5 min followed by 65 mmol over 24 h) or placebo. The end points were serious arrhythmias, left ventri cular ejection fraction (LVEF) and death during hospital stay and at t he end of 28 days. LVEF measured by radionuclide ventriculography at d ischarge (9 +/- 5 days) was similar in two groups(41 +/- 11 vs. 39 +/- 10; magnesium vs, placebo respectively, P = 0.40). However, the LVEF of the placebo-treated thrombolysed group was higher than the non-thro mbolysed group (42 +/- 10 vs. 37 +/- 0, P = 0.02). Incidence of nonsus tained ventricular tachycardia (NSVT) was higher with placebo than wit h magnesium (50% vs. 23% respectively, P < 0.02, odds ratio = 0.29; 95 % confidence intervals (CI) 0.1-0.85). Mortality during hospital stay and at the end of 28 days was also similar in both the groups. Thus, t he administration of magnesium infusion as an adjunct to thrombolytic therapy remains to be of questionable benefit.