SELECTIVE INTRAARTERIAL INFUSION OF HIGH-DOSE CISPLATIN IN PATIENTS WITH ADVANCED HEAD AND NECK-CANCER RESULTS IN HIGH TUMOR PLATINUM CONCENTRATIONS AND CISPLATIN-DNA ADDUCT FORMATION

Citation
G. Los et al., SELECTIVE INTRAARTERIAL INFUSION OF HIGH-DOSE CISPLATIN IN PATIENTS WITH ADVANCED HEAD AND NECK-CANCER RESULTS IN HIGH TUMOR PLATINUM CONCENTRATIONS AND CISPLATIN-DNA ADDUCT FORMATION, Cancer chemotherapy and pharmacology, 37(1-2), 1995, pp. 150-154
Citations number
26
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Pharmacy",Oncology
ISSN journal
0344-5704
Volume
37
Issue
1-2
Year of publication
1995
Pages
150 - 154
Database
ISI
SICI code
0344-5704(1995)37:1-2<150:SIIOHC>2.0.ZU;2-1
Abstract
A group of 23 patients with advanced head and neck cancer were treated with highly selective intra-arterial (IA) cisplatin 150 mg/m(2) deliv ered rapidly through microcatheters. The systemic effects of cisplatin were neutralized by concurrent administration of sodium thiosulfate. Two-to-threefold higher tumor platinum contents were detected in tumor biopsies after selective IA cisplatin administration compared to hist oricol controls (treated with 100 mg/m(2) IA), Cisplatin-induced DNA m odification in human tumor biopsies was quantitated using the antiseru m NKI-A59. High levels of cisplatin DNA adducts were detected which co rrelated linearly with the tumor platinum content (12 = 0.62). The add ition of radiotherapy to this high dose intensity cisplatin treatment resulted in a 92% complete response (CR) rate (12 of 13 patients achie ved a CR). Since no difference in tumor platinum content was detected between patients receiving or not receiving radiotherapy (13 and 10 pa tients, respectively), but the response rate was substantially differe nt (12 CR and 1 partial response with radiotherapy versus 6 partial an d 4 non-responders without radiotherapy), these data suggest that the high platinum levels achieved by selective IA infusion were sufficient to produce enough interaction with radiotherapy to cause a 92% CR rat e. Whether this interaction is additive or synergistic is as yet uncle ar.