PREVALENCE OF P53 OVEREXPRESSION OR MUTATIONS, BUT NOT K-RAS MUTATIONS, IN RECURRENT PATIENTS AFFECTED BY COLORECTAL-CARCINOMA

Citation
P. Iniesta et al., PREVALENCE OF P53 OVEREXPRESSION OR MUTATIONS, BUT NOT K-RAS MUTATIONS, IN RECURRENT PATIENTS AFFECTED BY COLORECTAL-CARCINOMA, International journal of oncology, 7(6), 1995, pp. 1319-1325
Citations number
42
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology
ISSN journal
1019-6439
Volume
7
Issue
6
Year of publication
1995
Pages
1319 - 1325
Database
ISI
SICI code
1019-6439(1995)7:6<1319:POPOOM>2.0.ZU;2-6
Abstract
In order to establish prognostic indicators of poor clinical evolution in colorectal cancer, we have studied p53 abnormalities and K-ras mut ations in 65 patients affected by colorectal carcinoma who had undergo ne radical surgery. A single event of p53 protein overexpression or p5 3 mutation, but not K-ras mutation, was significantly prevalent in rec urrent tumors. A double event of K-ras mutation and p53 protein overex pression was prevalent in patients showing Dukes' stage C, but showed a lack of prevalence in patients who recurred. The presence of p53 pro tein overexpression does not assure an underlying mutation in colorect al carcinoma.