M. Sasaki et al., MR ANATOMY OF THE SUBSTANTIA INNOMINATA AND FINDINGS IN ALZHEIMER-DISEASE - A PRELIMINARY-REPORT, American journal of neuroradiology, 16(10), 1995, pp. 2001-2007
Citations number
38
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences,"Radiology,Nuclear Medicine & Medical Imaging
PURPOSE: To demonstrate normal MR anatomy of the substantia innominata
and its changes in Alzheimer disease on MR imaging. METHODS: Using a
1.5-T superconductive MR unit, thickness of the substantia innominata
was measured on coronal thin-section images obtained in 22 patients wi
th Alzheimer disease and 14 age-matched control subjects. Comparison o
f these images with postmortem specimens of human brain was also perfo
rmed. RESULTS: On T2-weighted images through the anterior commissure,
the substantia innominata was clearly identified between the globus pa
llidus and the anterior perforated substance. In Alzheimer disease, th
inning of the substantia innominata was more frequently observed than
in the age-matched controls. CONCLUSION: Thin-section T2-weighted coro
nal MR images can demonstrate shrinkage of the substantia innominata,
a finding that may aid in the diagnosis of Alzheimer disease.